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decitabine or 5-aza-2'-deoxycytidine
Monitor:
- liver function tests at baseline [2]
Mechanism of action:
- pyrimidine analog incorporated into DNA, traps DNA methyltransferases, inhibitor of DNA hypermethylation in cancer
Notes:
in clinical trials for
- myelodysplastic syndrome
- CML
- acute myeloid leukemia
- other solid tumors (lung, ovary, prostate)
General
antineoplastic agent (chemotherapeutic agent)
pyrimidine antimetabolite; antimetabolite; pyrimidine analog
Database Correlations
PUBCHEM correlations
References
- Lyons et al.
Curr Opin Investig Drugs 4:1442-50, 2003
PMID: 14763130
- Prescriber's Letter 17(7): 2010
Recommended Lab Monitoring for Common Medications
Liver Function Test Scheduling
Detail-Document#: 260704
(subscription needed) http://www.prescribersletter.com