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disabled homolog 2; differentially-expressed protein 2; DOC-2 (DAB2, DOC2)
Function:
- component of the CSF-1 signal transduction pathway
- interacts with the globular tail of MYO6
- interacts with DAB2IP
- interacts with NOSTRIN (putative)
- binds to NPXY motif of the amyloid precursor protein (APP)
Structure: contains 1 PID domain
Compartment:
- cytoplasmic vesicle,
- clathrin-coated vesicle membrane
- membrane, clathrin-coated pit
- colocalizes with large insert-containing isoforms of MYO6 at clathrin-coated pits/vesicles
Alternative splicing: named isoforms=3
Expression:
- expressed in deep invaginations, inclusion cysts & the surface epithelial cells of the ovary
- also expressed in breast epithelial cells, spleen, thymus, prostate, testis, macrophages, fibroblasts, lung epithelial cells, placenta, brain stem, heart & small intestine
General
disabled homolog
phosphoprotein
Properties
SIZE: entity length = 770 aa
MW = 82 kD
COMPARTMENT: cytoplasm
MOTIF: phosphotyrosine interaction domain
NAME: phosphotyrosine interaction domain
SITE: 45-196
MOTIF: Thr phosphorylation site {T151}
Tyr phosphorylation site {Y170}
Thr phosphorylation site {T221}
Ser phosphorylation site {S227}
Tyr phosphorylation site {Y342}
Ser phosphorylation site {S393}
Ser phosphorylation site {S394}
Ser phosphorylation site {S401}
MYO6 interaction {649-770}
MOTIF: Ser phosphorylation site {S729}
Database Correlations
OMIM 601236
UniProt P98082
Pfam PF00640
Entrez Gene 1601
Kegg hsa:1601
References
- UniProt :accession P98082
- Entrez Gene :accession 1601