Search
disabled homolog 1 (DAB1)
Function:
- adapter molecule functioning in neural development
- required for layering of neurons in cerebral cortex & cerebellum, along with reelin, VLDL receptor & apolipoprotein E receptor 2
- may regulate SIAH1 activity (putative)
- phosphorylated on Tyr-198 & Tyr-220 upon reelin induction in embryonic neurons (putative)
- also phosphorylated on Ser-524 independently of reelin signaling (putative)
- associates with the SH2 domains of SRC, FYN & ABL
- interacts with DAB2IP & SIAH1 (putative)
- interacts with LRP1
Structure:
- PID domain specifically binds to Asn-Pro-Xaa-Tyr(P) motif found in many Tyr-phosphorylated proteins
- contains 1 PID domain
Alternative splicing: named isoforms=6
General
disabled homolog
phosphoprotein
Properties
SIZE: entity length = 588 aa
MW = 64 kD
MOTIF: phosphotyrosine interaction domain
NAME: phosphotyrosine interaction domain
SITE: 36-189
Tyr phosphorylation site {Y198}
Tyr phosphorylation site {Y220}
Ser phosphorylation site {S524}
Database Correlations
OMIM 603448
UniProt O75553
Pfam PF00640
Entrez Gene 1600
Kegg hsa:1600
References
- UniProt :accession O75553
- Entrez Gene :accession 1600