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disheveled-associated activator of morphogenesis 1 (DAAM1, KIAA0666)
Function:
1) binds to disheveled (Dvl) & Rho
2) mediates Wnt-induced Dvl-Rho complex formation
3) role as a scaffolding protein to recruit Rho-GDP & Rho-GEF, thereby, enhancing Rho-GTP formation
Structure:
1) belongs to the formin homology family
2) contains 1 DAD domain (diaphanous autoregulatory domain)
- contains 1 FH1 domain (formin homology 1 domain)
- contains 1 FH2 domain (formin homology 2 domain)
- contains 1 GBD/FH3 domain (Rho GTPase-binding/formin homology 3 domain)
Alternative splicing: named isoforms=3
Expression: expressed in all tissues examined
General
scaffold protein
Properties
SIZE: MW = 123 kD
entity length = 1078 aa
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: GBD/FH3 {45-420}
MOTIF: coiled coil {108-136}
glutamate-rich region {123-129}
MOTIF: glutamate residue (SEVERAL)
coiled coil {435-527}
FH1 {528-606}
MOTIF: proline-rich region
SITE: 550-558
MOTIF: proline residue (SEVERAL)
proline-rich region
SITE: 563-571
MOTIF: proline residue (SEVERAL)
proline-rich region
SITE: 574-582
MOTIF: proline residue (SEVERAL)
FH2 {608-991}
MOTIF: coiled coil {694-722}
coiled coil {883-911}
coiled coil {974-1071}
MOTIF: DAD {1027-1058}
Database Correlations
OMIM 606626
UniProt Q9Y4D1
PFAM correlations
References
UniProt :accession Q9Y4D1