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leiomodin-1; Leiomodin, muscle form; 64 kD autoantigen D1; 64 kD autoantigen 1D; 64 kD autoantigen 1D3; thyroid-associated ophthalmopathy autoantigen; smooth muscle leiomodin; SM-Lmod (LMOD1)
Structure:
- belongs to the tropomodulin family
- contains 1 WH2 domain
Compartment: cytoplasm, cytoskeleton
Alternative splicing: named isoforms=2
Expression:
- smooth muscle (heart, skeletal muscle, colon & small intestine), a subset of striated muscle fibers, & at low level in thyroid
Pathology:
- recognized by patients with autoimmune thyroid disease
Related
Hashimoto's thyroiditis; chronic lymphocytic thyroiditis; struma lymphomatosa; lymphadenoid goiter; primary myxedema
General
antigen
membrane protein
Properties
SIZE: entity length = 600 aa
MW = 67 kD
COMPARTMENT: cytoplasm
MOTIF: 8 X approximate tandem repeats {165-293}
MOTIF: consensus repeat {165-180}
consensus repeat {181-196}
consensus repeat {197-212}
consensus repeat {213-228}
consensus repeat {229-244}
consensus repeat {245-260}
consensus repeat {261-276}
consensus repeat {277-293}
membrane region
5 X 4 AA repeats {508-527}
WH2 {574-593}
Database Correlations
OMIM 602715
UniProt P29536
PFAM correlations
Entrez Gene 25802
Kegg hsa:25802
References
UniProt :accession P29536
Component-of
autoantigen d1/diosmin/hesperidin