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cytotoxic (suppressor) T cell (CD8+, CTL)

Characteristics: - CD3, CD8+ cells. - development of immature T-cell precursors (thymocytes) to CD8 T-cells correlates with their T-cell receptor specificity for major histocompatibility complex class 1 molecules. - absence of ZNF67 expression results in CD8+ cell commitment. CD8+ T-cells are involved in immune response to intracellular antigens & in cutaneous cytotoxic disorders. Normally 30% of circulating T-cells. Pool size: 1 x 10E11, 1/2 life = 167 days Pathology: - viral antigens can lead to misguided activation of CD8+ T-cells & development of lymphoproliferative disorders [2]

Related

CD4/CD8 ratio CD8

General

T lymphocyte (T-cell, thymocyte)

References

  1. Murasko DM & Berstein ED, Immunology of Aging, In: Principles of Geriatric Medicine, 4th ed,, Hazzard et al (eds), McGraw-Hill, NY, 1999, pg 99
  2. Wenzel J et al, The role of cytotoxic skin-homing CD8+ lymphocytes in cutaneous T-cell lymphoma and pityriasis lichenoides J Am Acad Dermatol 2005; 53:422 PMID: 16112347