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cytokine storm; cytokine cascade; hypercytokinemia
severe case of cytokine release syndrome
Pathology:
- potentially fatal positive feedback loop between cytokines & leukocytes
- renin angiotensin system has been implicated
Clinical manifestations:
- see cytokine release syndrome
Management:
- tocilizumab (Actemra) FDA-approved 8/2017
- investigational (potentially useful agents)
- targeting of OX40 & OX40L
- OX40 Ig
- simvastatin down-regulates OX40 & OX40L
- ACE inhibitor or ARB
- gemfibrozil
- TNF-alpha blockers
General
cytokine release syndrome
References
- Wikipedia: cytokine storm
http://en.wikipedia.org/wiki/Cytokine_storm
- Gever J
FDA Approves CAR T-Cell Therapy for Leukemia.
'First gene therapy available in the United States,' says
agency.
MedPage Today. August 30, 2017
https://www.medpagetoday.com/HematologyOncology/Leukemia/67615
- FDA News Release. Aug 30, 2017
FDA approval brings first gene therapy to the United States.
https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm574058.htm