cytokeratin-75 (keratin, type-2 cytoskeletal 75, keratin-75, type-2 keratin-18, type-2 keratin-K6hf, keratin-6 hair follicle, hK6hf, KRT75, K6HF, KB18)

Function: - role in hair & nail formation - component of keratin intermediate filaments in the companion layer of the hair follicle - may associate with KRT17 (putative) Structure: - heterotetramer of two type-1 & two type-2 keratins - belongs to the intermediate filament family Expression: - highly expressed in hair follicles from scalp - specifically expressed in the of the hair companion layer of the hair follicle - also expressed in medullated hairs - in nails, it is almost exclusively present in the nail bed (at protein level) Polymorphism: - the Thr-161 variant may increase risk to develop pseudofolliculitis barbae Pathology: - defects in KRT75 may be a cause of loose anagen hair syndrome

General

cytokeratin, epithelial keratins or soft alpha-keratins phosphoprotein

Properties

CONFIGURATION: oligomer SIZE: entity length = 551 aa MW = 60 kD COMPARTMENT: cytoplasm MOTIF: Head {1-148} MOTIF: glycine-rich region {39-120} Rod {149-458} MOTIF: Coil 1A {149-184} Linker 1 {185-203} Coil 1B {204-296} Linker 12 {297-319} Coil 2 {320-458} Ser phosphorylation site {S334} Stutter {400-400} Tail {459-551}

Database Correlations

OMIM 600628 UniProt O95678 Pfam PF00038 Kegg hsa:9119

References

UniProt :accession O95678