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keratin, type II cytoskeletal 7; cytokeratin-7; CK-7; keratin-7; K7; sarcolectin (KRT7, SCL)
Function:
- blocks interferon-dependent interphase
- stimulates DNA synthesis in cells
- interacts with eukaryotic translation initiator factor 3 (eIF3)
- subunit EIF3S10 of eIF3
Structure:
- heterotetramer of 2 type 1 & 2 type 2 keratins
- Arg-20 is dimethylated, probably to asymmetric dimethylarginine
- belongs to the intermediate filament family
Compartment: cytoplasm
Expression:
- subset of endothelial cells in normal tissues
- present in many simple, pseudostratified & ductal epithelia & mesothelial cells
- rare in colonic epithelium, hepatocytes, prostatic acinar cells
- expressed in cultured epidermal, bronchial & mesothelial cells but absent in colon, ectocervix & liver
- observed throughout the glandular cells in the junction between stomach & esophagus but is absent in the esophagus
- up-regulated by retinoic acid
Pathology:
- positive for antibody staining in
- mesothelioma
- transitional cell carcinoma
- neuroendocrine carcinoma
- thymic carcinoma
- breast carcinoma
- lung adenocarcinoma
- ovarian carcinoma
- endometrial carcinoma
- pancreatic adenocarcinoma
- fibrolamellar hepatocellular carcinoma
- mostly negative for antibody staining in
- renal cell carcinoma
- prostate cancer
- squamous cell carcinoma
- small cell carcinoma
- rare in colorectal adenocarcinoma
- other variams of hepatocellular carcinoma
- involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7)
Related
cytokeratin-7 Ag in tissue
cytokeratin-7+TTF1 Ag in tissue
General
cytokeratin, epithelial keratins or soft alpha-keratins
phosphoprotein
Properties
CONFIGURATION: oligomer
SIZE: entity length = 469 aa
MW = 51 kD
COMPARTMENT: cytoplasm
MOTIF: Head {2-90}
acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S7}
Ser phosphorylation site {S14}
Ser phosphorylation site {S45}
Coil 1A {90-126}
Rod {91-399}
MOTIF: HPV16 E7 interaction {92-97}
Linker 1 {127-144}
Coil 1B {145-236}
Tyr phosphorylation site {Y205}
Linker 12 {237-260}
Ser phosphorylation site {S252}
Ser phosphorylation site {S254}
Coil 2 {261-399}
glycine residue {343}
Tyr phosphorylation site {Y375}
Ser phosphorylation site {S380}
Tail {400-469}
Database Correlations
OMIM 148059
UniProt P08729
Pfam PF00038
Entrez Gene 3855
Kegg hsa:3855
References
- OMIM :accession 148059
- Dabbs. Diagnostic Immunohistochemistry. Churchill Livingstone
2002. pages 167-170.
- Entrez Gene :accession 3855