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keratin, type I cytoskeletal 24; cytokeratin-24; CK-24; keratin-24; K24; type I keratin-24 (KRT24 KA24)
Structure:
- type 1 cytokeratin
- heterotetramer of 2 type 1 & 2 type 2 keratins
- belongs to the intermediate filament family
Expression:
- highly expressed in keratinocytes, placenta, colon & spleen
- expressed at lower level in thymus & testis
Pathology:
- up-regulated in the mucosa of patients with colorectal cancer
General
cytokeratin, epithelial keratins or soft alpha-keratins
Properties
CONFIGURATION: oligomer
SIZE: entity length = 525 aa
MW = 55 kD
COMPARTMENT: cytoplasm
MOTIF: Head {1-139}
MOTIF: glycine-rich region {13-138}
O-glycosylation site {N-TERMINAL}
rod-like {central-region}
MOTIF: alpha helix
coiled coil
Rod {140-452}
MOTIF: Coil 1A {140-175}
Linker 1 {176-198}
Coil 1B {199-290}
Linker 12 {291-313}
Coil 2 {314-452}
glutamate-rich region {C-TERMINAL}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site (SEVERAL)
MOTIF-SEQUENCE: KSP
Tail {453-525}
Database Correlations
OMIM 607742
UniProt Q2M2I5
Pfam PF00038
Entrez Gene 192666
Kegg hsa:192666
References
UniProt :accession Q2M2I5