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keratin, type 1 cytoskeletal 15; cytokeratin-15; CK-15; keratin-15; K15 (KRT15 KRTB)
Structure:
- type 1 cytokeratin
- heterotetramer of 2 type 1 & tw2 type 2 keratins
- belongs to the intermediate filament family
Expression:
- expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis & nail
- also expressed in the outer root sheath above the hair bulb in hair follicle (at protein level)
- expressed homogeneously in all cell layers of the esophagus & exo-cervix, but detected in the basal cell layer only of oral mucosa, skin & in the basal plus the next two layers of the suprabasal epithelium of the palate
General
cytokeratin, epithelial keratins or soft alpha-keratins
Properties
CONFIGURATION: oligomer
SIZE: entity length = 456 aa
MW = 49 kD
COMPARTMENT: cytoplasm
MOTIF: Head {1-104}
MOTIF: glycine-rich region {14-103}
O-glycosylation site {N-TERMINAL}
rod-like {central-region}
MOTIF: alpha helix
coiled coil
Rod {105-413}
MOTIF: Coil 1A {105-140}
Linker 1 {141-159}
Coil 1B {160-251}
Linker 12 {252-271}
Coil 2 {272-413}
glutamate-rich region {C-TERMINAL}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site (SEVERAL)
MOTIF-SEQUENCE: KSP
Tail {414-456}
MOTIF: glycine-rich region {428-431}
Database Correlations
OMIM 148030
UniProt P19012
Pfam PF00038
Entrez Gene 3866
Kegg hsa:3866
References
- UniProt :accession P19012
- Entrez Gene :accession 3866