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keratin, type 1 cytoskeletal 13; cytokeratin-13; CK-13; keratin-13; K13 (KRT13)
Function:
- keratin-13 is generally associated with keratin-4
Structure:
- O-glycosylated; glycans consist of single N-acetylglucosamine residues
- heterotetramer of 2 type 1 & 2 type 2 keratins
- belongs to the intermediate filament family
Alternative splicing: named isoforms=2
Expression:
- expressed in some epidermal sweat gland ducts (at protein level) & in exocervix, esophagus & placenta
- suprabasal cells express keratins-4 & keratin-13
Pathology:
- defects in KRT13 are a cause of white sponge nevus of Cannon
General
cytokeratin, epithelial keratins or soft alpha-keratins
phosphoprotein
Properties
CONFIGURATION: oligomer
SIZE: entity length = 458 aa
MW = 50 kD
COMPARTMENT: cytoplasm
MOTIF: Head {1-103}
MOTIF: glycine-rich region {13-102}
Rod {104-412}
MOTIF: Coil 1A {104-139}
Linker 1 {140-158}
Coil 1B {159-250}
Linker 12 {251-273}
Coil 2 {274-412}
Tail {413-458}
MOTIF: Ser phosphorylation site {S427}
Database Correlations
OMIM correlations
MORBIDMAP 148065
UniProt P13646
Pfam PF00038
Entrez Gene 3860
Kegg hsa:3860
References
- UniProt :accession P13646
- Human intermediate Filament mutation Database
http://www.interfil.org
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=KRT13
- Wikipedia; Note: keratin-13 entry
http://en.wikipedia.org/wiki/keratin_13
- Entrez Gene :accession 3860