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cytochrome c (CYCS)

Function: - component of electron transport shuttling electrons from complex 3 to complex 4 - oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase (complex 3); cytochrome c then transfers this electron to the cytochrome oxidase complex, (complex 4) the final protein carrier in the mitochondrial electron-transport chain - plays a role in apoptosis - release from the inter mitochondrial membrane space into the cytoplasm through the bax subfamily protein-modified permeability transition pore complex (PTPC), activates APAF-1 which in turm activates caspase-9 to initiate apoptosis - cytochrome c is also thought to bind IP3 receptors in the endoplasmic reticulum membrane - this binding inhibits Ca+2 inhibitory feedback on the IP3 receptors resulting in prolonged release of Ca+2 from endoplasmic reticulum stores Structure: - belongs to the cytochrome c family - binds 1 heme group per subunit Compartment: - mitochondria matrix - mitochondrial intermembrane space

Interactions

molecular events

Related

apoptosis bax subfamily protein electron transport mitochondrial permeability transition pore complex (PTPC)

Specific

cytochrome c1 (cytochrome b-c1 complex subunit 4, ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit, CYC1)

General

cytochrome electron transport enzyme mitochondrial protein

Properties

SIZE: entity length = 105 aa MW = 12 kD COMPARTMENT: INTER-MITOCHODRIAL-MEMBRANE-SPACE MOTIF: heme-binding site [15-15] heme-binding site [18-18] Iron [Fe]-binding site SITE: 19-19 Iron [Fe]-binding site SITE: 81-81

Database Correlations

OMIM 123970 MORBIDMAP 123970 UniProt P99999 Kegg hsa/hsa04210

References

  1. Adams JM, Cory S. Life-or-death decisions by the Bcl-2 protein family. Trends Biochem Sci. 2001 Jan;26(1):61-6. Review. PMID: 11165519
  2. Sedlak TW, Snyder SH. Messenger molecules and cell death: therapeutic implications. JAMA. 2006 Jan 4;295(1):81-9. PMID: 16391220
  3. Protein Spotlight; Note: Life shuttle - Issue 76 of November 2006 http://www.expasy.org/spotlight/back_issues/sptlt076.shtml
  4. UniProt :accession P99999

Component-of

molecular complex