Search
cytochrome b558
General
cytochrome
flavoprotein
glycoprotein
multisubunit protein
plasma membrane protein
Properties
COMPARTMENT: plasma membrane
MOTIF: active site
SUBUNITS: cytochrome b558 alpha subunit (2)
MOTIF: transmembrane domain
Iron [Fe]-binding site
SITE: 93-93
proline-rich region
MOTIF: proline residue (SEVERAL)
cytochrome b558 beta subunit
MOTIF: cytoplasmic domain {1-7}
transmembrane domain {8-28}
exoplasmic loop {29-47}
transmembrane domain {48-68}
cytoplasmic loop {69-101}
MOTIF: Iron [Fe]-binding site
SITE: 100-100
transmembrane domain {102-122}
MOTIF: Iron [Fe]-binding site
SITE: 114-114
exoplasmic loop {123-168}
MOTIF: N-glycosylation site {N131}
N-glycosylation site {N148}
transmembrane domain {169-189}
cytoplasmic loop {190-199}
transmembrane domain {200-220}
MOTIF: Iron [Fe]-binding site
SITE: 208-208
exoplasmic loop {221-260}
MOTIF: Iron [Fe]-binding site
SITE: 221-221
N-glycosylation site {N239}
transmembrane domain {261-281}
cytoplasmic domain {282-569}
MOTIF: cofactor-binding site [337-343]
COFACTOR-BOUND: flavin adenine dinucleotide
References
- Rotrosen D, Yeung CL, Leto TL, Malech HL, Kwong CH.
Cytochrome b558: the flavin-binding component of the phagocyte
NADPH oxidase.
Science. 1992 Jun 5;256(5062):1459-62.
PMID: 1318579
- Segal AW, Abo A.
The biochemical basis of the NADPH oxidase of phagocytes.
Trends Biochem Sci. 1993 Feb;18(2):43-7. Review.
PMID: 8488557
Component-of
NADPH oxidase
Components
cytochrome b558 alpha subunit (p22 phagocyte B-cytochrome, neutrophil cytochrome B, 22 kD polypeptide, p21/p22phox, superoxide-generating NADPH oxidase light chain subunit, CYBA)
cytochrome b558 beta subunit (cytochrome b558 heavy chain, P22 phagocyte B-cytochrome, neutrophil cytochrome B 91 kD polypeptide, CGD91phox, gp91phox, heme binding membrane glycoprotein GP91PHOX, superoxide-generating NADPH oxidase heavy chain subunit, CYBB)