cytochrome b5 (CYB5A, CYB5)

Function: - membrane bound hemoprotein - electron carrier for several membrane bound oxygenases Structure: - belongs to the cytochrome b5 family - contains 1 cytochrome b5 heme-binding domain Compartment: - isoform 1: endoplasmic reticulum membrane, cytoplasmic side - isoform 2: cytoplasm Alternative splicing: named isoforms=2 Pathology: - defects in CYB5A are the cause of hereditary methemoglobinemia type 4 [MIM:250790]

General

cytochrome membrane protein

Properties

SIZE: entity length = 134 aa MW = 15 kD COMPARTMENT: cytoplasm endoplasmic reticulum MOTIF: heme-binding site [9-85] MOTIF: Iron [Fe]-binding site SITE: 44-44 Iron [Fe]-binding site SITE: 68-68 transmembrane domain {109-131}

Database Correlations

OMIM 250790 UniProt P00167 Pfam PF00173 Kegg hsa:1528

References

UniProt :accession P00167