Search
cytidine deaminase; cytidine aminohydrolase (CDA, CDD)
Function:
- scavenges exogenous and endogenous cytidine & 2'-deoxycytidine for UMP synthesis
cytidine + H2O uridine + NH3
Cofactor: Zn+2
Structure:
- homotetramer
- belongs to the cytidine & deoxycytidylate deaminase family
Expression:
- highly expressed in granulocytes
- expression is very low in fibroblasts, chondrocytes, monocytes, T-cell & B-cell lines
Genetics: Gene locus: 1p36.2-p35
Specific
DNA dC->dU-editing enzyme (phorbolin)
DNA dC->dU-editing enzyme APOBEC-3F (apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F, APOBEC3F)
General
cytidine deaminase family
Properties
SIZE: entity length = 146 aa
MW = 16 kD
MOTIF: Substrate binding {54-60}
Zn+2-binding site
SITE: 65-65
glutamate residue {E67}
active site
Zn+2-binding site
SITE: 99-99
Zn+2-binding site
SITE: 102-102
Database Correlations
OMIM 123920
UniProt P32320
Pfam PF00383
Entrez Gene 978
Kegg hsa:978
ENZYME 3.5.4.5
References
UniProt :accession P32320