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cytohesin-2; PH, SEC7 & coiled-coil domain-containing protein 2; ARF nucleotide-binding site opener; protein ARNO; ARF exchange factor (CYTH2 ARNO PSCD2 PSCD2L)
Function:
- promotes guanine-nucleotide exchange on ARF1, ARF3 & ARF6
- promotes activation of ARF through replacement of GDP with GTP
- heteromer composed of GRASP, CYTH2 & at least one GRM1 (putative)
- interacts with ARRB1
Structure:
- contains 1 PH domain
- contains 1 SEC7 domain
Alternative splicing: named isoforms=2
Expression: ubiquitous
Notes:
- ARNO may be cytohesin-2
General
cytohesin ADP Ribosylation Factor (ARF) nucleotide binding site opener (ARNO)
Properties
SIZE: entity length = 400 aa
MW = 47 kD
MOTIF: coiled coil {10-63}
coiled coil {N-TERMINAL}
sec7 domain
SITE: 72-201
guanine nucleotide exchange domain
NAME: guanine nucleotide exchange domain
PH domain {C-TERMINAL}
PH domain {259-376}
Database Correlations
OMIM 602488
UniProt Q99418
PFAM correlations
Entrez Gene 9266
Kegg hsa:9266
References
- UniProt :accession Q99418
- OMIM :accession 605081