Search
cytohesin-1; PH, SEC7 & coiled-coil domain-containing protein 1; SEC7 homolog B2-1; ARF nucleotide binding site opener-1; ARNO-1 (CYTH1, D17S811E, PSCD1)
Function:
- promotes guanine-nucleotide exchange on ARF1 & ARF5
- promotes the activation of ARF through replacement of GDP with GTP
- interacts with TRIM23 & CYTIP
Structure:
- contains 1 PH domain
- contains 1 SEC7 domain
Alternative splicing: named isoforms=2
Expression: ubiquitous
General
cytohesin ADP Ribosylation Factor (ARF) nucleotide binding site opener (ARNO)
Properties
SIZE: entity length = 398 aa
MW = 46 kD
MOTIF: coiled coil {10-67}
coiled coil {N-TERMINAL}
sec7 domain
SITE: 73-202
guanine nucleotide exchange domain
NAME: guanine nucleotide exchange domain
PH domain {C-TERMINAL}
PH domain {260-377}
Database Correlations
OMIM 182115
UniProt Q15438
PFAM correlations
Entrez Gene 9267
Kegg hsa:9267
References
- UniProt :accession Q15438
- OMIM :accession 182115