cytochrome P450 reductase selections

NADPH dependent cytochrome P450 reductase (CPR, P450R, POR, CYPOR)

Function: - reduces cytochrome P450 & heme oxygenase - required for electron transfer from NADP to cytochrome P450 in microsomes - can also provide electron transfer to heme oxygenase & cytochrome B5 NADPH + n oxidized hemoprotein NADP+ + n reduced hemoprotein Cofactor: FAD, FMN Structure: - in the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family - contains 1 FAD-binding domain - contains 1 flavodoxin-like domain Compartment: - endoplasmic reticulum membrane - peripheral membrane protein - anchored to the ER membrane by its N-terminal hydrophobic region Pathology: - defects in POR are the cause of adrenal hyperplasia variant type & of isolated disordered steroidogenesis (same OMIM) [3]

General

cytochrome reductase

Properties

SIZE: entity length = 677 aa MW = 77 kD COMPARTMENT: endoplasmic reticulum MOTIF: Flavodoxin-like {80-224} binding site SITE: 274-493 FOR-BINDING-OF: flavin adenine dinucleotide MOTIF: cofactor-binding site [314-325] COFACTOR-BOUND: flavin adenine dinucleotide cofactor-binding site [451-461] COFACTOR-BOUND: flavin adenine dinucleotide cofactor-binding site [529-547] COFACTOR-BOUND: NADP cofactor-binding site [623-639] COFACTOR-BOUND: NADP

Database Correlations

OMIM correlations MORBIDMAP 124015 UniProt P16435 PFAM correlations ENZYME 1.6.2.4

References

UniProt :accession P16435
GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=POR
OMIM :accession 201750

Component-of

multienzyme complex