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cytochrome P450 3A5 (P450-PCN3, CYP3A5)
Function:
1) NADPH-dependent electron transport pathway
2) oxidizes a variety of structurally unrelated compounds, including
- steroids, fatty acids, xenobiotics
Structure: belongs to the cytochrome P450 family
Compartment: membrane-bound, endoplasmic reticulum
Expression: expressed in liver
Laboratory:
- CYP3A5 gene mutation
General
cytochrome P450 3A (CYP3A)
Properties
SIZE: MW = 57 kD
entity length = 502 aa
COMPARTMENT: endoplasmic reticulum
MOTIF: Iron [Fe]-binding site
SITE: 441-441
Database Correlations
OMIM 605325
UniProt P20815
Pfam PF00067
Entrez Gene 1577
Kegg hsa:1577
ENZYME 1.14.14.1
References
- UniProt :accession P20815
- Cytochrome P450 Allele Nomenclature committee, CYP3A5 alleles
http://www.cypalleles.ki.se/cyp3a5.htm