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cytochrome P450 2E1 (ethanol-inducible cytochrome P450, CYP2E1)
Function:
1) metabolizes several procarcinogens, drugs, & solvents to reactive metabolites
- involved in metabolism of nitrosamines
2) inducers
- ethanol
- isoniazid
3) substrates
- eszopiclone
- isoniazid
Compartment: membrane-bound, endoplasmic reticulum
Expression: induced by ethanol & isoniazid
Related
CYP2E
CYP2E1 gene mutation
General
cytochrome P450
Properties
SIZE: calculated = 56.9 kD
entity length = 493 aa
COMPARTMENT: smooth endoplasmic reticulum
MOTIF: membrane region
heme-binding site [cysteine residue]
COFACTOR-BOUND: heme
SUBSTRATE: eszopiclone
isoniazid
INDUCERS: ethanol
isoniazid
Database Correlations
OMIM 124040
UniProt P05181
Pfam PF00067
Entrez Gene 1571
Kegg hsa:1571
ENZYME 1.14.14.1
References
- OMIM :accession 124040
- UniProt :accession P05181
- Cytochrome P450 Allele Nomenclature committee, CYP2E1 alleles
http://www.cypalleles.ki.se/cyp2e1.htm
- Wikipedia, CYP2E1 entry
http://en.wikipedia.org/wiki/CYP2E1