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CYP2C19 genotyping; CYP2C19 allele testing
Indications:
- predicting efficacy of clopidogrel (maybe)
Specimen:
- buccal swabs
- blood: 5-10 cc whole blood lavender-top EDTA or Yellow-top ACD-A tubes
Interpretation:
- turnaround time: 10 days (5 days for STAT tests)
Specific
CYP2C19 gene mutation
General
genotyping (allele testing)
References
- Cytochrome P450 2C19 Genotyping
Genelex
http://www.healthanddna.com/healthcare-professional/p450-2c19-genotyping.html
- Bauer T et al.
Impact of CYP2C19 variant genotypes on clinical efficacy of
antiplatelet treatment with clopidogrel: Systematic review
and meta-analysis.
BMJ 2011 Aug 4; 343:d4588
PMID: 21816733
- Holmes MV et al.
CYP2C19 genotype, clopidogrel metabolism, platelet function,
and cardiovascular events: A systematic review and meta-analysis.
JAMA 2011 Dec 28; 306:2704.
PMID: 22203539
- Nissen SE.
Pharmacogenomics and clopidogrel: Irrational exuberance?
JAMA 2011 Dec 28; 306:2727.
PMID: 22203545
- CYP2C19 Allele 2
Laboratory Test Directory ARUP: 51104
Component-of
CYP2D6 & CYP2C19 genotyping panel