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cytochrome P450 17A1; cytochrome P450 C17; steroid-17-alpha hydroxylase; steroid 17-alpha-hydroxylase/17,20 lyase; CYPXVII; P450-C17; P450c17; steroid 17-alpha-monooxygenase (CYP17A1, CYP17, S17AH)
Function:
1) steroid 17,20 lyase, involved in testosterone & estradiol synthesis
2) conversion of pregnenolone to dehydroepiandrosterone (DHEA); 17-alpha-hydroxypregnenolone is an intermediate
3) conversion of progesterone to androstenedione; 17-alpha-hydroxyprogesterone is an intermediate
4) catalyzes both 17-alpha-hydroxylation & 17,20-lyase phosphorylation is necessary for 17,20-lyase, but not for 17alpha-hydroxylase activity
4) involved in sexual development during fetal life & at puberty
5) regulated predominantly by intracellular cAMP levels
Pathology:
- deficiency associated with congenital adrenal hyperplasia type-5
Pharmacology:
- inhibitor abiraterone acetate may be useful for treatment of castration-resistanct prostate cancer
Laboratory:
- CYP17A1 gene mutation
Related
abiraterone acetate (Zytiga)
congenital adrenal hyperplasia (21-hydroxlase deficiency)
CYP17A1 gene mutation
steroid biosynthesis
General
cytochrome P450
steroid hydroxylase
Properties
SIZE: entity length = 508 aa
MW = 57 kD
COMPARTMENT: smooth endoplasmic reticulum
MOTIF: membrane region
active site
Iron [Fe]-binding site
SITE: 442-442
Database Correlations
OMIM 202110
UniProt P05093
Pfam PF00067
Entrez Gene 1586
Kegg hsa:1586
ENZYME 1.14.99.9
References
- OMIM :accession 202110
- UniProt :accession P05093
- SHMPD, The Singapore human mutation and polymorphism database
http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=CYP17A1
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=CYP17A
Component-of
multienzyme complex