cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121, CYFIP2, KIAA1168, PIR121)

Function: 1) role in T-cell adhesion & p53-dependent induction of apoptosis 2) does not bind RNA 3) interacts with FMR1, FXR1 & FXR2 4) component of WAVE1 complex 5) CYFIP2 binds to activated RAC1 which causes WAVE1 complex to dissociate, releasing activated WASF1 Structure: belongs to the CYFIP family Compartment: - cytoplasm, perinuclear region - synaptosome - hghly expressed in the perinuclear region - enriched in synaptosomes - treatment with leptomycin-B triggers translocation to nucleus Alternative splicing: named isoforms=2 RNA editing: - modified positions=320, partially edited - editing appears to be brain-specific Pathology: - up-regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis (at protein level)

Properties

SIZE: MW = 148 kD entity length = 1278 aa COMPARTMENT: cytoplasm cell nucleus

Database Correlations

OMIM 606323 UniProt Q96F07

References

UniProt :accession Q96F07