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cyclin H (MO15-associated protein, CCNH)
Function:
- cyclin component of CDK-activating kinase
- regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex
- CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 & CDK6 by threonine phosphorylation
- CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase 2 by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter & elongation of the transcripts
- involved in cell cycle control & in RNA transcription by RNA polymerase 2
- expression & activity are constant throughout the cell cycle
- associates primarily with CDK7 & MAT1 to form the CAK complex
- CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor
Structure: belongs to the cyclin family. cyclin C subfamily
Compartment: nucleus
General
cyclin
phosphoprotein
Properties
SIZE: entity length = 323 aa
MW = 38 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S5}
Ser phosphorylation site {S304}
glutamate-rich region {310-313}
MOTIF: glutamate residue (SEVERAL)
Thr phosphorylation site {T315}
Database Correlations
OMIM 601953
UniProt P51946
Pfam PF00134
Entrez Gene 902
Kegg hsa:902
References
- Solomon MJ.
The function(s) of CAK, the p34cdc2-activating kinase.
Trends Biochem Sci. 1994 Nov;19(11):496-500.
PMID: 7855894
- UniProt :accession P51946
Component-of
CDK7/cyclin H complex, CDK-activating kinase (CAK) or p34cdc2 activating kinase