cyclin G1 (CCNG1, CCNG, CYCG1)

Function: - may play a role in growth regulation - associated with G2/M phase arrest in response to DNA damage - may be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (putative) - activated by actinomycin-D induced DNA damage Structure: belongs to the cyclin family, cyclin G subfamily Compartment: - nucleus - DNA replication foci after DNA damage Expression: - high levels in skeletal muscle, ovary, kidney & colon - very low levels in normal cells during G1 phase, which increase as cells enter the S phase & stay high throughout the S & G2/M phases Pathology: - in breast cancer cells consistent high levels are found throughout the cell cycle - activated in breast & prostate cancer cells

Properties

SIZE: entity length = 295 aa MW = 34 kD COMPARTMENT: cell nucleus MOTIF: ubiquitination site (destruction box, D-box) SITE: N-TERMINAL FOR-BINDING-OF: ubiquitin cyclin box FOR-BINDING-OF: cyclin-dependent kinase phosphorylation site

Database Correlations

OMIM 601578 UniProt P51959 Pfam PF00134 Entrez Gene 900 Kegg hsa:900

References

UniProt :accession P51959