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G1/S-specific cyclin-D3 (CCND3)
Function:
- essential for the control of the cell cycle at the G1/S (start) transition
- potentiates the transcriptional activity of ATF5
- interacts with the CDK4 & CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex
- the cyclin subunit imparts substrate specificity to the complex
- interacts with ATF5
- interacts with EIF3K
Structure:
- belongs to the cyclin family, cyclin D subfamily
Compartment: cytoplasm, nucleus
Related
CCND3 gene
General
cyclin D
Properties
SIZE: entity length = 292 aa
MW = 33 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Ser phosphorylation site {S263}
Ser phosphorylation site {S279}
Database Correlations
OMIM 123834
UniProt P30281
PFAM correlations
Entrez Gene 896
Kegg hsa:896
References
- UniProt :accession P30281
- NIEHS-SNPs
http://egp.gs.washington.edu/data/ccnd3/