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CDK4/cyclin D1 complex
The CDK4/cyclin D1 complex governs G1 progression.
General
CDK4/cyclin D complex
Properties
STATE: active state
SUBUNITS: cyclin-dependent kinase-4 (CDK4)
STATE: active state
MOTIF: Thr phosphorylation site {N-TERMINAL}
Tyr phosphorylation site {N-TERMINAL}
kinase domain
MOTIF: ATP-binding site
NAME: ATP-binding site
PSTAIRE motif
MOTIF-SEQUENCE: PSTAIRE
Thr-phosphate
binding site
EFFECTOR-BOUND: cyclin D1
BOUND-VIA: cyclin box
Thr-phosphate {T172}
cyclin D1
MOTIF: ubiquitination site (destruction box, D-box)
SITE: N-TERMINAL
FOR-BINDING-OF: ubiquitin
PEST region
cyclin box
EFFECTOR-BOUND: cyclin-dependent kinase-4 (CDK4)
BOUND-VIA: binding site
LXC motif
FOR-BINDING-OF: retinoblastoma-associated protein
glutamate-rich region
MOTIF: glutamate residue (9)
References
Cordon-Cardo AmJ Pathol 147:545 1995
Components
cyclin D1 (parathyroid adenomatosis-1 [PRAD1] protein or bcl-1 proto-oncogene protein, CCND1, BCL1)
cyclin-dependent kinase-4 (CDK4) or PSK-J3