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cyclin D
G1-specific cyclin. Complexes with CDK4 or CDK6. Binds to Rb protein.
Specific
cyclin D1 (parathyroid adenomatosis-1 [PRAD1] protein or bcl-1 proto-oncogene protein, CCND1, BCL1)
cyclin D2 (CCND2)
G1/S-specific cyclin-D3 (CCND3)
General
cyclin
Figures/Diagrams
Figures/diagrams/slides/tables related to cyclin D
Properties
SIZE: MW = 45-62 kD
COMPARTMENT: cell nucleus
CELL-CYCLE: G1
MOTIF: ubiquitination site (destruction box, D-box)
SITE: N-TERMINAL
FOR-BINDING-OF: ubiquitin
PEST region
cyclin box
FOR-BINDING-OF: cyclin-dependent kinase
LXC motif
FOR-BINDING-OF: retinoblastoma-associated protein
References
- Cordon-Cardo C.
Mutations of cell cycle regulators. Biological and clinical
implications for human neoplasia.
Am J Pathol. 1995 Sep;147(3):545-60. Review.
PMID: 7677168
Component-of
CDK4/cyclin D complex