Contents

Search

cyclin B

Function: - G2 & G2/M-phase specific cyclin [3] Expression: - under transcriptional control [2]

Interactions

molecular events

Specific

cyclin B1 (CCNB1) cyclin B2 (CCNB2) G2/mitotic-specific cyclin-B3 (CCNB3, CYCB3)

General

cyclin

Properties

SIZE: MW = 45-62 kD COMPARTMENT: cell nucleus CELL-CYCLE: G2 MOTIF: ubiquitination site (destruction box, D-box) SITE: N-TERMINAL FOR-BINDING-OF: ubiquitin PEST region cyclin box FOR-BINDING-OF: cyclin-dependent kinase

References

  1. Hunter T. Cooperation between oncogenes. Cell. 1991 Jan 25;64(2):249-70. Review. PMID: 1988147
  2. Morgan DO. Principles of CDK regulation. Nature. 1995 Mar 9;374(6518):131-4. Review. PMID: 7877684
  3. Cordon-Cardo C. Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia. Am J Pathol. 1995 Sep;147(3):545-60. Review. PMID: 7677168

Component-of

CDK1/cyclin B complex or maturation promoting factor (MPF)