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cyclic neutropenia (cyclic hematopoiesis)

Pathology: - blood-cell production from the bone marrow oscillates with 21-day periodicity - during intervals of neutropenia, affected individuals are at risk for opportunistic infection - monocytes, platelets, lymphocytes & reticulocytes also cycle with the same frequency Genetics: - autosomal dominant disease - associated with defects in ELA2 Laboratory: - circulating neutrophils vary between almost normal numbers & zero

General

familial neutropenia

Database Correlations

OMIM 162800

References

  1. Saunders Manual of Medical Practice, Rakel (ed), WB Saunders, Philadelphia, 1996, pg 587-89
  2. UniProt :accession P08246
  3. OMIM :accession 162800