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high affinity interleukin-8 receptor B; IL-8R B; CXCR-2; GRO/MGSA receptor; IL-8 receptor type 2; CDw128b; CD182 (IL8RB, CXCR2)
Function:
- receptor for interleukin-8
- binding of IL-8 causes activation of neutrophils
- response is mediated via a G-protein that activates a phosphatidylinositol-Ca+2 second messenger system
- binds to IL-8 with high affinity
- also binds with high affinity to CXCL3, GRO/MGSA & NAP-2
- phosphorylated upon ligand binding; which is required for desensitization
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
CXC chemokine receptor
interleukin-8 receptor (IL8 receptor)
phosphoprotein
Properties
SIZE: entity length = 360 aa
MW = 41 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {1-48}
MOTIF: N-glycosylation site {N22}
transmembrane domain {49-75}
cytoplasmic loop {76-84}
transmembrane domain {85-105}
exoplasmic loop {106-120}
MOTIF: cysteine residue {C119}
MODIFICATION: cysteine residue {C196}
transmembrane domain {121-142}
cytoplasmic loop {143-163}
transmembrane domain {164-183}
exoplasmic loop {184-208}
MOTIF: cysteine residue {C196}
MODIFICATION: cysteine residue {C119}
transmembrane domain {209-231}
cytoplasmic loop {232-251}
transmembrane domain {252-273}
exoplasmic loop {274-294}
transmembrane domain {295-315}
cytoplasmic domain {316-360}
MOTIF: Ser phosphorylation site {S347}
Ser phosphorylation site {S351}
Ser phosphorylation site {S352}
Ser phosphorylation site {S353}
References
- UniProt :accession P25025
- Wikipedia; CXC chemokine receptors entry
http://en.wikipedia.org/wiki/CXC_chemokine_receptors
- SeattleSNPs
http://pga.gs.washington.edu/data/il8rb/
- Wu D et al
G protein-coupled signal transduction pathways for
interleukin-8.
Science 261:101 1993
PMID: 8316840
Databases & Figures
OMIM 146928
UniProt P25025
Pfam PF00001
Entrez Gene 3579
Kegg hsa:3579
CXC ligand and receptor binding