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high affinity interleukin-8 receptor A; IL-8R A; IL-8 receptor type 1; CXCR-1; CDw128a; CD181 (IL8RA, CMKAR1, CXCR1)
Function:
- receptor to interleukin-8
- binding of IL-8 to the receptor causes activation of neutrophils
- response is mediated via a G-protein that activate a phosphatidylinositol-Ca+2 second messenger system
- binds to IL-8 with a high affinity & to MGSA (GRO) with low affinity
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Interactions
molecular events
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
CXC chemokine receptor
glycoprotein
interleukin-8 receptor (IL8 receptor)
Properties
SIZE: entity length = 350 aa
MW = 40 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {1-39}
MOTIF: N-glycosylation site {N3}
N-glycosylation site {N16}
transmembrane domain {40-66}
cytoplasmic loop {67-75}
transmembrane domain {76-96}
exoplasmic loop {97-111}
MOTIF: cysteine residue {C110}
MODIFICATION: cysteine residue {C187}
transmembrane domain {112-133}
cytoplasmic loop {134-154}
transmembrane domain {155-174}
exoplasmic loop {175-199}
MOTIF: cysteine residue {C187}
MODIFICATION: cysteine residue {C110}
transmembrane domain {200-220}
cytoplasmic loop {221-242}
transmembrane domain {243-264}
exoplasmic loop {265-285}
transmembrane domain {286-308}
cytoplasmic domain {309-350}
References
- UniProt :accession P25024
- Wikipedia; CXC chemokine receptors entry
http://en.wikipedia.org/wiki/CXC_chemokine_receptors
- SeattleSNPs
http://pga.gs.washington.edu/data/il8ra/
- Wu D et al
G protein-coupled signal transduction pathways for
interleukin-8.
Science 261:101 1993
PMID: 8316840
Databases & Figures
OMIM 146929
MORBIDMAP 146929
UniProt P25024
Pfam PF00001
Entrez Gene 3587
Kegg hsa:3577
CXC ligand and receptor binding