Search
VEGF co-regulated chemokine 1 (C-X-C motif chemokine 17, Dendritic cell & monocyte chemokine-like protein, DMC, CXCL17, VCC1, UNQ473/PRO842)
Function:
- role in angiogenesis & possibly in the development of tumors
- may be a housekeeping chemokine regulating recruitment of nonactivated blood monocytes & immature dendritic cells into tissues
- may play a role in the innate defense against infections
Structure:
- belongs to the intercrine alpha (chemokine CxC) family
Compartment: secreted
Expression:
- detected in trachea, stomach, lung & skeletal muscle
- detected in intestine & in normal & asthmatic lung (at protein level)
- detected in fetal lung
Pathology:
- breast cancer with 3-24 fold up-regulation
- up-regulated in duodenal mucosa during acute cholera
General
CXC chemokine; alpha chemokine
Properties
SIZE: entity length = 119 aa
MW = 14 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-21}
cysteine residue {C50}
MODIFICATION: cysteine residue {C75}
cysteine residue {C52}
MODIFICATION: cysteine residue {C77}
cysteine residue {C75}
MODIFICATION: cysteine residue {C50}
cysteine residue {C77}
MODIFICATION: cysteine residue {C52}
Database Correlations
UniProt Q6UXB2
References
- UniProt :accession Q6UXB2
- Wikipedia CXCL17 entry
http://en.wikipedia.org/wiki/CXCL17
Component-of
carbinoxamine/dextromethorphan/pseudoephedrine/vegf co regulated chemokine 1