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C-X-C motif chemokine 13; angie; B cell-attracting chemokine 1; BCA-1; B lymphocyte chemoattractant; CXC chemokine BLC; small-inducible cytokine B13 (CXCL13, BCA1, BLC, SCYB13)
Function:
- chemotactic for B-lymphocytes
- not chemotactic for T-lymphocytes, monocytes or neutrophils
- does not induce Ca+2 release in B- lymphocytes
- binds to BLR1/CXCR5
- aryl hydrocarbon receptor is a potent negative regulator of CXCL13 production by human CD4+ T-cells
Structure:
- belongs to the intercrine alpha (chemokine CxC) family
Compartment: secreted
Expression:
- highest levels in liver, followed by spleen, lymph node, appendix & stomach
- low levels in salivary gland, mammary gland & fetal spleen
- aryl hydrocarbon receptor coordinates with JUN to prevent CXCL13+ T-cell differentiation & promote an IL-22+ phenotype
Pathology:
- in connection with IFN-alpha & aryl hydrocarbon receptor plays a role in systemic lupus erythematosus
Related
CXCL13 Ag in CSF
CXCL13 Ag in tissue
General
CXC chemokine; alpha chemokine
Properties
SIZE: entity length = 109 aa
MW = 13 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-22}
cysteine residue {C33}
MODIFICATION: cysteine residue {C60}
cysteine residue {C35}
MODIFICATION: cysteine residue {C76}
cysteine residue {C60}
MODIFICATION: cysteine residue {C33}
cysteine residue {C76}
MODIFICATION: cysteine residue {C35}
References
- UniProt :accession O43927
- Wikipedia; Note: CXCL13 entry
http://en.wikipedia.org/wiki/CXCL13
- Law C, Wacleche VS, Cao Y et al
Interferon subverts an AHR-UN axis to promote CXCL13+ T cells in lupus.
Nature. 2024 Jul 10. doi: 10.1038/s41586-024-07627-2
PMID: 38987586
https://www.nature.com/articles/s41586-024-07627-2
Databases & Figures
OMIM 605149
UniProt O43927
Pfam PF00048
Entrez Gene 10563
Kegg hsa:10563
CXC ligand and receptor binding