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growth-regulated alpha protein; C-X-C motif chemokine 1; GRO-alpha(1-73); melanoma growth stimulatory activity; MGSA; neutrophil-activating protein 3; NAP-3; contains: GRO-alpha(4-73); GRO-alpha(5-73); GRO-alpha(6-73) (CXCL1, GRO, GRO1, GROA, MGSA, SCYB1)
Function:
- MGSA binds to IL-8 receptor-beta
- does not bind IL-8 receptor-alpha
- chemotactic for neutrophils [2]
- may play a role in inflammation
- exerts autocrine effects on endothelial cells
- N-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73) & GRO-alpha(6-73) are produced by proteolytic cleavage after secretion from peripheral blood monocytes
- in vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) & GRO-alpha(6-73) show a 30-fold higher chemotactic activity than CXCL1
Structure:
- belongs to the intercrine alpha (chemokine CxC) family
Compartment: secreted
Comparative biology:
- MGSA is the protein product of gro (human) or KC (mouse) gene
Related
gro or KS gene
high affinity interleukin-8 receptor B; IL-8R B; CXCR-2; GRO/MGSA receptor; IL-8 receptor type 2; CDw128b; CD182 (IL8RB, CXCR2)
General
CXC chemokine; alpha chemokine
gro proto-oncogene protein
Properties
SIZE: entity length = 107 aa
MW = 11 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-34}
cysteine residue {C43}
MODIFICATION: cysteine residue {C69}
cysteine residue {C45}
MODIFICATION: cysteine residue {C85}
cysteine residue {C69}
MODIFICATION: cysteine residue {C43}
cysteine residue {C85}
MODIFICATION: cysteine residue {C45}
SECRETED-BY: fibroblast
melanocyte
References
- Cross M, Dexter TM.
Growth factors in development, transformation, and tumorigenesis.
Cell. 1991 Jan 25;64(2):271-80. Review.
PMID: 1988148
- Hopkins SJ & Rothwell NJ
Cytokines and the nervous system. I: Expression and recognition.
TINS 18:83 1995
PMID: 7537419
- UniProt :accession P09341
- Wikipedia; Note: CXCL1 entry
http://en.wikipedia.org/wiki/CXCL1
Databases & Figures
OMIM 155730
UniProt P09341
Pfam PF00048
Entrez Gene 2919
Kegg hsa:2919
CXC ligand and receptor binding