CX3C chemokine receptor 1; C-X3-C CKR-1; CX3CR1; fractalkine receptor; G-protein coupled receptor 13; V28; beta chemokine receptor-like 1; CMK-BRL-1; CMKBLR1 (CX3CR1, CMKBRL1, GPR13)

Function: - receptor for the CX3C chemokine fractalkine & mediates both its adhesive & migratory functions Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane; multi-pass membrane protein Alternative splicing: named isoforms=3 Expression: expressed in lymphoid & neural tissues Pathology: - coreceptor with CD4 for HIV-1 virus envelope protein (in vitro) - isoform 2 & isoform 3 seem to be more potent HIV coreceptors than isoform 1 Polymorphism: - variations in CX3CR1 are associated with rapid progression to AIDS; increased susceptibility to HIV infection & rapid progression to AIDS are associated with the Ile-249/Met-280 haplotype

General

chemokine receptor (chemoattractant receptor) G-protein coupled receptor; serpentine receptor

Properties

SIZE: entity length = 355 aa MW = 40 kD COMPARTMENT: plasma membrane MOTIF: exoplasmic domain {1-31} transmembrane domain {32-59} cytoplasmic loop {60-69} transmembrane domain {70-90} exoplasmic loop {91-103} MOTIF: cysteine residue {C102} MODIFICATION: cysteine residue {C175} transmembrane domain {104-125} cytoplasmic loop {126-142} transmembrane domain {143-167} exoplasmic loop {168-195} MOTIF: cysteine residue {C175} MODIFICATION: cysteine residue {C102} transmembrane domain {196-215} cytoplasmic loop {216-231} transmembrane domain {232-256} exoplasmic loop {257-273} transmembrane domain {274-297} cytoplasmic domain {298-355}

Database Correlations

OMIM correlations MORBIDMAP 601470 UniProt P49238 Pfam PF00001 Entrez Gene 1524 Kegg hsa:1524

References

UniProt :accession P49238