CUB & zona pellucida-like domain-containing protein 1 (transmembrane protein UO-44, CUZD1)

Function: - role in uterus during late pregnancy &/or in trypsin activation in pancreatic acinar cells Structure: - contains 2 CUB domains - contains 1 ZP domain Compartment: membrane Alternative splicing: named isoforms=4 Expression: detected in pancreas & epithelium of ovary Pathology: - expressed at higher levels in ovarian tumors than in normal tissue - CUZD1 antiserum inhibits cell attachment & proliferation of ovarian cancer cells

General

glycoprotein membrane protein

Properties

SIZE: MW = 68 kD entity length = 607 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-24} MOTIF: cysteine residue {C17} MODIFICATION: cysteine residue {C58} CUB domain {25-146} MOTIF: N-glycosylation site {N29} N-glycosylation site {N57} cysteine residue {C58} MODIFICATION: cysteine residue {C17} N-glycosylation site {N67} cysteine residue {C85} MODIFICATION: cysteine residue {C107} cysteine residue {C107} MODIFICATION: cysteine residue {C85} CUB domain {154-265} MOTIF: cysteine residue {C154} MODIFICATION: cysteine residue {C180} cysteine residue {C180} MODIFICATION: cysteine residue {C154} cysteine residue {C207} MODIFICATION: cysteine residue {C229} cysteine residue {C229} MODIFICATION: cysteine residue {C207} ZP domain {276-519} MOTIF: cysteine residue {*1} MODIFICATION: cysteine residue {*2} cysteine residue {*2} MODIFICATION: cysteine residue {*1} N-glycosylation site {N394} N-glycosylation site {N419} transmembrane domain {569-589}

Database Correlations

UniProt Q86UP6 PFAM correlations

References

UniProt :accession Q86UP6