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Cullin-2; CUL-2 (CUL2)
Function:
- core component of multiple cullin-RING-based ECS complex(es)
- the E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit & is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (putative)
- protein modification; protein ubiquitination
- CBC(VHL) complex formation seems to promote neddylation
- deneddylated via its interaction with the COP9 signalosome (CSN complex) (putative)
- component of the ECS(VHL) or CBC(VHL) complex
- component of the ECS(MED8) complex with the probable substrate recognition component MED8 (putative)
- component of the ECS(PPIL5) complex with the probable
- substrate recognition component PPIL5
- component of a probable ECS E3 ubiquitin-protein ligase complex containing CUL2, RBX1, TCEB1, TCEB2 & FEM1B.
- part of an E3 ubiquitin-protein ligase complex including ZYG11B, CUL2 & elongin BC
- part of an E3 ubiquitin-protein ligase complex including ZYG11BL, CUL2 & elongin BC.
- interacts with RBX1, RNF7, FEM1B & TIP120A/CAND1
- interacts with COPS2, & MED8 (putative)
- interacts with human respiratory syncytial virus (HRSV) protein NS1
Structure: belongs to the cullin family
General
cullin
phosphoprotein
Properties
SIZE: entity length = 745 aa
MW = 87 kD
MOTIF: Tyr phosphorylation site {Y394}
Thr phosphorylation site {T661}
References
- UniProt :accession Q13617
- Entrez Gene :accession 8453
Component-of
ECS complex; elonginB/C-CUL2/5-SOCS-box protein complex; ECS E3 ubiquitin-protein ligase complex
Databases & Figures
OMIM 603135
UniProt Q13617
PFAM correlations
Entrez Gene 8453
Kegg hsa:8453
HIF-1 pathway