Contents

Search

cullin homolog 1 (CUL-1)

Function: - core component of SCF complex(es) - component of the SCF(FBXW11) complex containing FBXW11 - component of the SCF(SKP2) complex containing SKP2, in which it interacts directly with SKP1, SKP2 & RBX1 - component of the SCF(FBXW2) complex containing FBXw2 - component of the SCF(FBXO32) complex containing FBXO32 - component of the probable SCF(FBXO7) complex containing FBXO7 - component of the SCF(FBXO11) complex containing FBXO11 - component of the SCF(FBXO25) complex containing FBXO25 - component of the SCF(FBXO33) complex containing FBXO33 - component of the probable SCF(FBXO4) complex containing FBXO4 - component of the SCF(BTRC) complex, composed of SKP1, CUL1 & BTRC; this complex binds phosphorylated NFKBIA - in the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein & RBX1 subunits - may contribute to catalysis through positioning of the substrate & the ubiquitin-conjugating enzyme - the E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit & is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 - neddylation enhances ubiquitination activity of SCF - deneddylated via its interaction with the CSN complex (COP9 signalosome complex) - interacts with RNF7 - selectively interacts with SKP1 & forms complex with SKP2 & cyclin A - part of a complex with TIP120A/CAND1 & RBX1 - the unneddylated form interacts with TIP120A/CAND1 & the interaction negatively regulates the association with SKP1 in the SCF complex - interacts with COPS2. can self-associate - interacts with FBXW8. - interacts with CUL7; the interaction seems to be mediated by FBXW8 Structure: belongs to the cullin family Expression: expressed in lung fibroblasts

General

cullin scaffold protein

Properties

SIZE: MW = 90 kD entity length = 776 aa COMPARTMENT: synaptic membrane CELL: neuron MOTIF: membrane region binding site SITE: 720-720 FOR-BINDING-OF: ubiquitin

Database Correlations

OMIM 603134 UniProt Q13616 PFAM correlations Entrez Gene 8454 Kegg hsa:8454

References

  1. UniProt :accession Q13616
  2. OMIM :accession 603134
  3. Entrez Gene :accession 8454

Component-of

SKP1-CUL1-F-box protein (SCF) complex; SCF(FBXW11) E3 ligase complex; CF(SKP2) E3 ligase complex