catenin delta-2; delta-catenin; neural plakophilin-related ARM-repeat protein; NPRAP; neurojungin; GT24 (CTNND2, NPRAP)

Function: - transcriptional activator when bound to ZBTB33 (putative) - may be involved in neuronal cell adhesion & tissue morphogenesis & integrity by regulating adhesion molecules - binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain - interacts with PDZD2 - interacts with ZBTB33 (putative) - binds to PSEN1 - interacts with RGNEF - interacts (via C-terminus) with FRMPD2 (via 2nd PDZ domain) - phosphorylated upon DNA damage, probably by ATM or ATR - phosphorylated by CDK5 Structure: - O-glycosylated (putative) - belongs to the beta-catenin family - contains 9 ARM repeats Compartment: - nucleus (putative) - cell junction, adherens junction (putative) Alternative splicing: - named isoforms=2 - additional isoforms seem to exist Expression: predominantly expressed in brain

General

beta catenin family protein catenin human longevity protein phosphoprotein

Properties

SIZE: entity length = 1225 aa MW = 133 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S32} coiled coil {49-84} proline-rich region SITE: 216-226 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S267} Ser phosphorylation site {S276} ARM repeat {394-438} MOTIF: Ser phosphorylation site {S415} Ser phosphorylation site {S474} Tyr phosphorylation site {Y516} Ser phosphorylation site {S534} Ser phosphorylation site {S537} ARM repeat {540-579} ARM repeat {582-621} ARM repeat {626-666} ARM repeat {682-724} ARM repeat {728-773} lysine-rich region {811-817} MOTIF: lysine residue (SEVERAL) ARM repeat {835-875} ARM repeat {882-921} ARM repeat {975-1018} Ser phosphorylation site {S1072} Ser phosphorylation site {S1076} Ser phosphorylation site {S1127}

Database Correlations

OMIM 604275 UniProt Q9UQB3 Pfam PF00514 Entrez Gene 1501 Kegg hsa:1501