catenin delta-1; p120 catenin; p120(ctn); cadherin-associated Src substrate; CAS; p120(cas) (CTNND1, KIAA0384)

Function: - binds to & inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (putative) - may associate with & regulate cell adhesion properties of both C-cadherin & E-cadherin - implicated both in cell transformation by SRC & in ligand- induced receptor signaling through the EGFR, PDGFR, CSF1R & ERBB2 - promotes GLIS2 C-terminal cleavage - belongs to a multiprotein cell-cell adhesion complex that also contains E-cadherin, alpha-catenin, beta-catenin, & gamma- catenin - binds to the C-terminal fragment of PSEN1 & mutually competes for E-cadherin - interacts with ZBTB33 - interacts with GLIS2 - phosphorylated (putative) Structure: - a possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted - belongs to the beta-catenin family - contains 10 ARM repeats Compartment: - cytoplasm. nucleus. cell membrane - interaction with GLIS2 promotes nuclear translocation (putative) Alternative splicing: named isoforms=32 Expression: - expressed in vascular endothelium - induced in vascular endothelium by wounding; this effect is potentiated by prior laminar shear stress, which enhances wound closure Pathology: - may contribute to cell malignancy - complete loss of expression was observed in ~ 10% of invasive ductal breast carcinomas

General

beta catenin family protein catenin phosphoprotein

Properties

SIZE: entity length = 968 aa MW = 108 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: coiled coil {10-46} Ser phosphorylation site {S47} Tyr phosphorylation site {Y96} Tyr phosphorylation site {Y174} Tyr phosphorylation site {Y217} Tyr phosphorylation site {Y228} Ser phosphorylation site {S230} Ser phosphorylation site {S232} Ser phosphorylation site {S244} Tyr phosphorylation site {Y257} Ser phosphorylation site {S268} Ser phosphorylation site {S269} Tyr phosphorylation site {Y280} Ser phosphorylation site {S288} Tyr phosphorylation site {Y291} Tyr phosphorylation site {Y302} Thr phosphorylation site {T310} Ser phosphorylation site {S320} Tyr phosphorylation site {Y321} Tyr phosphorylation site {Y334} Ser phosphorylation site {S349} Ser phosphorylation site {S352} ARM repeat {358-395} ARM repeat {398-437} ARM repeat {441-475} ARM repeat {476-516} ARM repeat {534-573} ARM repeat {583-624} nuclear translocation signal {622-634} ARM repeat {653-693} ARM repeat {700-739} ARM repeat {740-780} ARM repeat {781-826} Ser phosphorylation site {S859} Tyr phosphorylation site {Y865} Thr phosphorylation site {T869} Tyr phosphorylation site {Y904} Thr phosphorylation site {T916}

Database Correlations

OMIM 601045 UniProt O60716 Pfam PF00514 Kegg hsa:1500

References

UniProt :accession O60716