Search
catenin alpha-1; cadherin-associated protein; alpha E-catenin; NY-REN-13 antigen (CTNNA1)
Function:
- associates with the cytoplasmic domain of a variety of cadherins
- may play a role in cell differentiation
- binds MLLT4 & F-actin (putative)
- interacts directly with PSEN1 & CTNNB1 to form part of the PSEN1/cadherin/catenin adhesion complex
- interacts with ARHGAP21 & with JUB
- sumoylated
Structure: belongs to the vinculin/alpha-catenin family
Compartment:
- cytoplasm, cytoskeleton
- cell junction, adherens junction
- cell membrane, cytoplasmic side
- found at cell-cell boundaries & probably at cell-matrix boundaries
Alternative splicing: named isoforms=2
Expression: expressed ubiquitously in normal tissues
Pathology:
- abnormalities of alpha-catenin are involved in the process of cancer invasion & metastasis
General
alpha catenin
phosphoprotein
Properties
SIZE: entity length = 906 aa
MW = 100 kD
COMPARTMENT: cytoplasm
MOTIF: Tyr phosphorylation site {Y177}
Tyr phosphorylation site {Y619}
Ser phosphorylation site {S641}
Thr phosphorylation site {T645}
Ser phosphorylation site {S652}
Thr phosphorylation site {T654}
Ser phosphorylation site {S655}
Thr phosphorylation site {T658}
References
- UniProt :accession P35221
- Takeichi M.
Cadherin cell adhesion receptors as a morphogenetic regulator.
Science. 1991 Mar 22;251(5000):1451-5. Review.
PMID: 2006419
Databases & Figures
OMIM 116805
UniProt P35221
Pfam PF01044
Entrez Gene 1495
Kegg hsa:1495
E-cadherin/CD31 ... F-actin