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connective tissue growth factor; CCN family member 2; hypertrophic chondrocyte-specific protein 24; insulin-like growth factor-binding protein 8; IBP-8; IGF-binding protein 8; IGFBP-8 (CTGF, CCN2, HCS24 ,IGFBP8)
Function:
- major connective tissue mitoattractant secreted by vascular endothelial cells
- promotes proliferation & differentiation of chondrocytes
- mediates heparin- & divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial cells & epithelial cells
- enhances fibroblast growth factor-induced DNA synthesis
Structure:
- monomer
- belongs to the CCN family
- contains 1 CTCK (C-terminal cystine knot-like) domain
- contains 1 IGFBP N-terminal domain
- contains 1 TSP type-1 domain
- contains 1 VWFC domain
Compartment:
- secreted, extracellular space, extracellular matrix (putative)
Alternative splicing: named isoforms=2
Expression:
- expressed in bone marrow & thymus
- also expressed one of two Wilms tumors tested
Laboratory:
- connective tissue growth factor in urine
General
glycoprotein
growth factor
secreted protein
Properties
SIZE: entity length = 349 aa
MW = 38 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-26}
IGFBP N-terminal {27-98}
MOTIF: N-glycosylation site {N28}
VWFC domain {101-167}
TSP1 module {198-243}
MOTIF: N-glycosylation site {N225}
binding site
SITE: 247-349
FOR-BINDING-OF: heparin
MOTIF: C-terminal cystine knot {256-330}
cysteine residue {C256}
MODIFICATION: cysteine residue {C293}
cysteine residue {C273}
MODIFICATION: cysteine residue {C307}
cysteine residue {C284}
MODIFICATION: cysteine residue {C323}
cysteine residue {C287}
MODIFICATION: cysteine residue {C325}
cysteine residue {C292}
MODIFICATION: cysteine residue {C329}
cysteine residue {C293}
MODIFICATION: cysteine residue {C256}
cysteine residue {C307}
MODIFICATION: cysteine residue {C273}
cysteine residue {C323}
MODIFICATION: cysteine residue {C284}
cysteine residue {C325}
MODIFICATION: cysteine residue {C287}
cysteine residue {C329}
MODIFICATION: cysteine residue {C292}
Database Correlations
OMIM 121009
UniProt P29279
PFAM correlations
Entrez Gene 1490
Kegg hsa:1490
References
- UniProt :accession P29279
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/CTGFID40192ch6q23.html