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CTF18-replication factor C

Function: - binds to single-stranded & primed DNAs - weak ATPase activity stimulated by PCNA - catalyzes the ATP-dependent loading of PCNA onto primed & gapped DNA - interacts with & stimulates DNA polymerase POLH - interacts with & stimulates POLN, which is suggestive of a protein network that coordinates DNA repair, recombination & chromosome cohesion reactions with replication fork progression - does not interact with the Rad9/Rad1/Hus1 complex Structure: - subunits: CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 & RFC5

Related

replication factor-C

General

molecular complex

Properties

SUBUNITS: chromosome transmission fidelity protein 18 homolog COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S74} ATP-binding site NAME: ATP-binding site SITE: 374-381 Ser phosphorylation site {S871} chromosome transmission fidelity protein 8 homolog COMPARTMENT: cell nucleus sister chromatid cohesion protein DCC1 COMPARTMENT: cell nucleus replication factor C subunit 2 MOTIF: ATP-binding site NAME: ATP-binding site replication factor C subunit 3 COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S125} replication factor C subunit 4 COMPARTMENT: cell nucleus MOTIF: ATP-binding site NAME: ATP-binding site SITE: 78-85 replication factor C subunit 5 COMPARTMENT: cell nucleus MOTIF: ATP-binding site NAME: ATP-binding site SITE: 60-67

References

  1. UniProt :accession Q7Z7C8

Components

chromosome transmission fidelity protein 18 homolog (hCTF18, CHTF18, CTF18) chromosome transmission fidelity protein 8 homolog; hCTF8 (CHTF8, CTF8) replication factor C subunit 2 (replication factor C 40 kD subunit, RF-C 40 kD subunit, RFC40, activator 1 40 kD subunit, A1 40 kD subunit, RFC2) replication factor C subunit 3 (replication factor C p38, replication factor C 38 kD subunit, RFC38, activator 1 38 kD subunit, A1 38 kD subunit, RF-C 38 kD subunit, RFC3) replication factor C subunit 4 (replication factor C p37, replication factor C 37 kD subunit, RF-C 37 kD subunit, RFC37, activator 1 37 kD subunit, A1 37 kD subunit, RFC4) replication factor C subunit 5 (replication factor C p36, RF-C 36 kD subunit, RFC36, activator 1 36 kD subunit, A1 36 kD subunit, RFC5) sister chromatid cohesion protein DCC1 (DCC1, DSCC1)