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cysteine & glycine-rich protein 3; cysteine-rich protein 3; CRP3; cardiac LIM protein; LIM domain protein, cardiac; muscle LIM protein (CSRP3, CLP, MLP)
Function:
- positive regulator of myogenesis
- could play a role in mechanical stretch sensing
- interacts with LDHD (putative)
Structure:
- contains 2 LIM Zn+2-binding domains
Compartment:
- nucleus (putative)
- cytoplasm, cytoskeleton (putative)
- nuclear, associates with the actin cytoskeleton (putative)
Expression:
- cardiac muscle & slow-twitch skeletal muscles
Pathology:
- defects in CSRP3 are the cause of
a) cardiomyopathy dilated type 1M
b) cardiomyopathy familial hypertrophic type 12
Notes: also see cysteine-rich protein 3
General
LIM domain protein
nuclear protein
Properties
SIZE: entity length = 194 aa
MW = 21 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: LIM domain {10-61}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
glycine-rich region {63-78}
MOTIF: nuclear translocation signal {64-69}
LIM domain {120-171}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
glycine-rich region {177-185}
Database Correlations
OMIM correlations
MORBIDMAP 600824
UniProt P50461
Pfam PF00412
Entrez Gene 8048
Kegg hsa:8048
References
- UniProt :accession P50461
- GeneReviews
http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/CSRP3