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chondroitin sulfate proteoglycan 4 (chondroitin sulfate proteoglycan NG2, melanoma chondroitin sulfate proteoglycan, melanoma-associated chondroitin sulfate proteoglycan, CSPG4, MCSP, MEL-CSPG, MSK16)
Function:
1) proteoglycan
2) cell proliferation & migration
3) stimulates endothelial cells motility during microvascular morphogenesis
4) inhibits neurite outgrowth & growth cone collapse during axon regeneration
5) cell surface receptor for collagen-6 alpha-2
- facilitates migration on collagen-6 alpha-2
6) binds extracellular matrix proteases, modulates activity
7) regulates MPP16-dependent degradation
8) enhances plasminogen activation (putative)
9) inhibits angiostatin (putative)
10) signal transduction via binding scaffold proteins (putative)
11) retraction fiber formation & cell polarization via Rho GTPase activation.
12) stimulates alpha-4 integrin & beta-1 integrin mediated adhesion
13) recruits activates a signaling cascade through CDC42, ACK1 & BCAR1 (putative)
14) activate FAK & ERK1/ERK2 signaling cascades (putative)
15) interacts with the first PDZ domain of MPDZ
16) interacts with PRKCA
17) binds TNC, laminin-1, COL5A1, COL6A2
18) interacts with PLG & angiostatin
19) binds FGF2 & PDGFA
20) interacts with GRIP1, GRIP2 & GRIA2
- forms a ternary complex with GRIP1 & GRIA2 (putative)
21) interacts with LGALS3 & the integrin (ITGB1/ITGA3)
22) interacts with ITGA4 through its chondroitin sulfate glycosaminoglycan
23) interacts with BCAR1, CDC42 & ACK1
24) interacts with MMP16
25) N-glycosylated O-glycosylated
- contains glycosaminoglycan chondroitin sulfate
26) phosphorylation by PRKCA regulates its subcellular location & function in cell motility
27) contains 15 CSPG (NG2) repeats
- contains 2 laminin G-like domains
Compartment:
- cell membrane
- localized at the apical plasma membrane
- relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA
- localizes to the retraction fibers
- localizes to the plasma membrane of oligodendrocytes
Pathology:
- detected in malignant melanoma cells
General
phosphoprotein
proteoglycan core protein
Properties
SIZE: MW = 250 kD
entity length = 2322 aa
MOTIF: signal sequence {1-29}
LAMININ G-LIKE 1 {30-192}
domain {30-639}
MOTIF: Neurite growth inhibition {30-639}
N-glycosylation site {N130}
cysteine residue {C169}
MODIFICATION: cysteine residue {C192}
cysteine residue {C192}
MODIFICATION: cysteine residue {C169}
LAMININ G-LIKE 2 {202-380}
N-glycosylation site {N348}
cysteine residue {C354}
MODIFICATION: cysteine residue {C380}
cysteine residue {C380}
MODIFICATION: cysteine residue {C354}
N-glycosylation site {N427}
CSPG {430-523}
CSPG {556-643}
binding site
SITE: 574-1040
FOR-BINDING-OF: collagen 6 alpha-2
binding site
SITE: 631-1446
FOR-BINDING-OF: collagen 5 alpha-1
serine-rich region {639-1586}
MOTIF: serine residue (SEVERAL)
CSPG {665-1561} (8)
N-glycosylation site {N685}
N-glycosylation site {N772}
CSPG {1583-1679}
Neurite growth inhibition {1586-2221}
MOTIF: CYS-containing. {1587-2221}
N-glycosylation site {N1645}
CSPG {1707-2147} (4)
N-glycosylation site {N2075}
transmembrane domain {2225-2245}
Thr phosphorylation site {T2252}
PDZ recognition motif
NAME: PDZ recognition motif
SITE: 2320-2322
FOR-BINDING-VIA: PDZ domain
Database Correlations
OMIM 601172
UniProt Q6UVK1
Pfam PF02210
References
UniProt :accession Q6UVK1