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microtubule-associated protein tau in CSF

Indications: - may be useful for evaluation of tauopathy - may be useful for detecting Alzheimer's-related neurodegeneration & differentiating Alzheimer's disease from other neurodegenerative diseases [2] Physiology: - CSF tau levels are higher during wakefulness than sleep - brain-derived microtubule-associated protein tau differs from peripherally-derived tau that contains an exon 4a insert between exons 4 & 5* * see brain-derived microtubule-associated protein tau in serum/plasma Clinical significance: - CSF tau increases 10 years before onset of dementia [3]

Related

cerebrospinal fluid microtubule-associated protein tau (neurofibrillary tangle protein, paired helical filament-tau, PHF-tau, MAPT, MTBT1, m-tau, mtau) microtubule-associated protein tau in serum/plasma tauopathy

Specific

phosphorylated tau in CSF

General

microtubule-associated protein tau in body fluid

References

  1. Lucey BP, McCullough A, Landsness EC et al Reduced non-rapid eye movement sleep is associated with tau pathology in early Alzheimer's disease. Sci Transl Med. 2019 Jan 9;11(474). PMID: 30626715 - Holth JK et al. The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans. Science 2019 Feb 22; 363:880. PMID: 30679382 PMID: 30679382 http://science.sciencemag.org/content/363/6429/880 - Noble W, Spires-Jones TL. Sleep well to slow Alzheimer's progression? Science 2019 Feb 22; 363:813 PMID: 30679382 http://science.sciencemag.org/content/363/6429/813
  2. George J Novel Blood Test Detects Alzheimer's Neurodegeneration. Brain-derived tau distinguished Alzheimer's from other dementias. MedPage Today December 30, 2022 https://www.medpagetoday.com/neurology/alzheimersdisease/102459 - Gonzales-Ortiz F, Turton M, Kac PR et al Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease- type neurodegeneration. Brain. 2022. Dec 27. PMID: 36572122 https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awac407/6960988
  3. Jia J et al. Biomarker changes during 20 years preceding Alzheimer's Disease. N Engl J Med 2024 Feb 21; 390:712-722 PMID: 38381674 https://www.nejm.org/doi/10.1056/NEJMoa2310168

Component-of

microtubule-associated protein tau/total protein in CSF Tau/Abeta42 in CSF; amyloid-tau neurodegeneration (ATN) profile