CSF for beta amyloid 1-42 & tau

Indications: - Alzheimer's disease Clinical significance: - CSF from patients with Alzheimer's disease vs control: analyte Alzheimer's disease* control beta-amyloid 1-42: 183 pg/mL 491 pg/mL tau: 587 pg/mL 244 pg/mL false negatives: 8% false positives: 11% * Most diagnoses not yet confirmed by autopsy

References

Journal Watch 23(10):91, 2003 Sutherland T et al, JAMA April 23/30 289:2094, 2003 http://jama.ama-assn.org/cgi/content/full/289/16/2094