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macrophage colony-stimulating factor 1; CSF-1; M-CSF; MCSF; Lanimostim (CSF1)
Function:
- cytokine that induces cells of the monocyte/macrophage lineage
- role in immunological defenses, bone metabolism, lipoprotein clearance, fertility & pregnancy
- glycosylation & proteolytic cleavage yield different soluble forms
- a high molecular weight soluble form is a proteoglycan containing chondroitin sulfate
- isoform 1 is N- & O-glycosylated
- isoform 3 is N-glycosylated
- homodimer or heterodimer; disulfide-linked
Compartment:
- cell membrane; single-pass membrane protein
- processed macrophage colony-stimulating factor 1: secreted, extracellular space (putative)
Alternative splicing: named isoforms=3
Interactions
molecular events
Related
macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; CSF-1-R; CSF-1R; M-CSF-R; proto-oncogene c-Fms; CD115 (CSF1R, FMS)
General
colony-stimulating factor (CSF)
oligomerizing protein
Properties
CONFIGURATION: dimer
SIZE: entity length = 554 aa
MW = 60 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-32}
cysteine residue {C39}
MODIFICATION: cysteine residue {C122}
cysteine residue {C63}
MODIFICATION: cysteine residue {C-INTERCHAIN}
cysteine residue {C80}
MODIFICATION: cysteine residue {C171}
cysteine residue {C122}
MODIFICATION: cysteine residue {C39}
cysteine residue {C134}
MODIFICATION: cysteine residue {C178}
N-glycosylation site {N154}
cysteine residue {C171}
MODIFICATION: cysteine residue {C80}
N-glycosylation site {N172}
cysteine residue {C178}
MODIFICATION: cysteine residue {C134}
cysteine residue {C189}
MODIFICATION: cysteine residue {C-INTERCHAIN}
cysteine residue {C191}
MODIFICATION: cysteine residue {C-INTERCHAIN}
transmembrane domain {497-517}
SECRETED-BY: fibroblast
monocyte
endothelial cell
Database Correlations
OMIM 120420
UniProt P09603
Pfam PF05337
Entrez Gene 1435
Kegg hsa:1435
References
- UniProt :accession P09603
- Henderson B & Blake S
Therapeutic potential of cytokine manipulation
TIPS 13:145 1992
PMID: 1589908